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Research Supporting Hyperbaric Oxygen Therapy (HBOT)

HBOT Mechanism

 

  •  Thom SR. "Hyperbaric oxygen: its mechanisms and efficacy." Plastic and Reconstructive Surgery. 2011;127(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf.

Link:https://journals.lww.com/plasreconsurg/fulltext/2011/01001/hyperbaric_oxygen__its_mechanisms_and_efficacy.23.aspx


  • AL, Bell CNA. "Hyperbaric oxygen: its uses, mechanisms of action and outcomes." QJM: An International Journal of Medicine. 2004;97(7):385–395. doi:10.1093/qjmed/hch074.

Link: https://academic.oup.com/qjmed/article/97/7/385/1567601

HBOT and General Health

 

  • Fife CE, Eckert KA, Carter MJ. "An update on the appropriate role for hyperbaric oxygen: indications and evidence." Plastic and Reconstructive Surgery. 2016;138(3 Suppl):107S–116S. doi:10.1097/PRS.0000000000002714.

Link:https://journals.lww.com/plasreconsurg/Fulltext/2016/09001/An_Update_on_the_Appropriate_Role_for_Hyperbaric.15.aspx

  • Thom SR. "Oxidative stress is fundamental to hyperbaric oxygen therapy." Journal of Applied Physiology (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008.

Link: https://journals.physiology.org/doi/full/10.1152/japplphysiol.91004.2008

HBOT and Dementia/Alzheimer’s

 

  • Harch PG, Fogarty EF. "Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report." Medical Gas Research. 2019;8(4):181–184. Published 2019 Jan 9. doi:10.4103/2045-9912.248271.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347177/

  • Shapira R, Efrati S, Ashery U. "Hyperbaric oxygen therapy as a new approach for Alzheimer’s disease." Neural Regeneration Research. 2018;13(5):817–818. doi:10.4103/1673-5374.232475.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953028/

HBOT and Fibromyalgia

 

  • Efrati S, Hadanny A, Daphna-Tekoah S, et al. "Recovery of repressed memories in fibromyalgia patients managed with hyperbaric oxygen–case series presentation and suggested bio-psycho-social mechanism." Frontiers in Psychology. 2018;9:848. doi:10.3389/fpsyg.2018.00848.

Link: https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00848/full

HBOT Sports Performance and Recovery

 

  • Seymour et al. "Hyperbaric Oxygen Therapy Enhances Athletic Recovery Through Physiological Adaptations." Frontiers in Physiology. 2021;12:791872. doi:10.3389/fphys.2021.791872.

Link: https://www.frontiersin.org/articles/10.3389/fphys.2021.791872/full

  • Shaw et al. "The Impact of Hyperbaric Oxygen Therapy on Athletic Performance and Recovery: A Comprehensive Review." Sports Medicine - Open. 2021;7(1):403. doi:10.1186/s40798-021-00403-w.

Link: https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-021-00403-w

HBOT and Autism

 

  • Rossignol DA, Rossignol LW, Smith S, et al. "Hyperbaric for children with autism: a multicenter, randomized, double-blind, controlled trial." BMC Pediatrics. 2009;9:21. doi:10.1186/1471-2431-9-21.

Link: https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-9-21

  • Xiong T, Chen H, Luo R, et al. "Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD)." Cochrane Database of Systematic Reviews. 2016;10. doi:10.1002/14651858.CD010922.pub2.

Link: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010922.pub2/full

HBOT and Wound Healing

 

  • Perren S, Gatt A, Papanas N, et al. "Hyperbaric oxygen therapy in ischemic foot ulcers in type 2 diabetes: a clinical trial." Open Cardiovascular Medicine Journal. 2018;12:80–85. Published 2018 Aug 31. doi:10.2174/1874192401812010080.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135494/

  • Eskes AM, Ubbink DT, Lubbers MJ, et al. "Hyperbaric oxygen therapy: solution for difficult-to-heal acute wounds? Systematic review." World Journal of Surgery. 2011;35(3):535–542. doi:10.1007/s00268-010-0923-4.

Link: https://link.springer.com/article/10.1007/s00268-010-0923-4

HBOT and TBI/Concussion

 

  • Tal S, Hadanny A, Sasson E, et al. "Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients." Frontiers in Human Neuroscience. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508.

Link: https://www.frontiersin.org/articles/10.3389/fnhum.2017.00508/full

  • Meng XE, Zhang Y, Li N, et al. "Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway." Medical Science Monitor. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730336/

HBOT and Stroke Recovery

 

  • Efrati S, Fishlev G, Bechor Y, et al. "Hyperbaric oxygen induces late neuroplasticity in post-stroke patients–randomized, prospective trial." PLoS One. 2013;8(1):e53716. doi:10.1371/journal.pone.0053716.

Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053716

  • Liska GM, Lippert T, Russo E, et al. "A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells." Conditioning Medicine. 2018;1(4):151–166.

Link: https://www.condmed.org/articles/A-Dual-Role-for-Hyperbaric-Oxygen-in-Stroke-Neuroprotection-Preconditioning-of-the-Brain-and-Stem-Cells/108

HBOT and Pain-Inflammation

 

  • Meng XE, Zhang Y, Li N, et al. "Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway." Medical Science Monitor. 2016;22:284–288. doi:10.12659/msm.894148.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730336/

  • Dulai PS, Gleeson MW, Taylor D, et al. "Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease." Alimentary Pharmacology & Therapeutics. 2014;39(12):1266–1275. doi:10.1111/apt.12753.

Link: https://onlinelibrary.wiley.com/doi/10.1111/apt.12753

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